Publications

 

2020

Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene

Eozenou C.*, Gonen N.*, Touzon MS.*, Jorgensen A, Yatsenko SA., Fusee L., Kamel AK., Gellen B., Guercio G., Singh P., Witchel S., Berman AJ., Mainpal R., Totonchi M.,Meybodi AM., Askari M., Merel-Chali T.,Bignon-Topalovic J., Migale R., Costanzo M., Marino R., Ramirez P., Garrido NP., Berensztein E., Mekkawy MK., Schimenti JC., Bertalan R., Mazen I., McElreavey K., Belgorosky A., Lovell-Badge R., Rajkovic A., Bashamboo A. (2020) Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene. Proc Natl Acad Sci USA

* These authors have equally contributed to this paper

2019

Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination

Garcia-Moreno SA., Futtner CR., Salamone IM., Gonen N., Lovell-Badge R., Maatouk DM. (2019) Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination. Dev Biol, 446(2): 168-179.

2019

Regulation of Sox9 expression in the Gonads

Gonen N.*, Lovell-Badge R.*. (2019) The Regulation of Sox9 expression in the Gonads. Curr Tops Dev Biol. 134:223-252 Review Article

*Co-corresponding authors

2018

Sex Reversal Following Deletion of a Single Far Upstream Enhancer of Sox9

Gonen N., Futtner CR., Wood S., Garcia-Moreno SA., Salamone IM., Samson SC., Sekido R., Poulat F., Maatouk DM., Lovell-Badge R. (2018) Sex Reversal Following Deletion of a Single Far Upstream Enhancer of Sox9. Science, 360 (6396):1469-1473 

- Recommended by Faculty of 1000 as Exceptional

- Featured in Science 

2017

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone

Gonen N., Quinn A., O'Neill HC., Koopman P., Lovell-Badge R. (2017) Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 13(1).

2014

Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.

Raz S., Sheban D., Gonen N., Stark M., Berman B., Assaraf YG. (2014) Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest. Cell Death Dis. 20;5.

2014

Homothorax plays autonomous and non-autonomous roles in proximodistal axis formation and migration of the Drosophila renal tubules

Zohar-Stoopel A. *, Gonen N. *, Mahroum M., Ben-Zvi DS., Toledano H., Salzberg A. (2014) Homothorax plays autonomous and non-autonomous roles in proximodistal axis formation and migration of the Drosophila renal tubules. Dev Dyn. 243(1):132-44         

*These authors have equally contributed to this paper.

2012

Antifolates in Cancer Therapy: Structure, Activity and Mechanisms of Drug Resistance

Gonen N. and Assaraf YG. (2012) Antifolates in Cancer Therapy: Structure, Activity and Mechanisms of Drug Resistance. Drug Resist Updat 15(4): 183-210. Review Article

2010

The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 (NRF-1)

Gonen N. and Assaraf YG. (2010) The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 (NRF-1). J. Biol. Chem. 285(44): 33602-13.

2009

Functional elements in the minimal promoter of the human proton-coupled folate transporter

Stark M.*, Gonen N.*, Assaraf YG. (2009) Functional elements in the minimal promoter of the human proton-coupled folate transporter. Biochem. Biophys. Res. Commun. 388(1): 79-85.                   

*These authors have equally contributed to this paper.

2008

PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells

Gonen N., Bram EE., Assaraf YG. (2008) PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells. Biochem Biophys. Res. Commun. 376(4): 787-92. 

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