Publications

Gonen N.*, Eozenou C.*, Mitter R., Elzaiat M, Stévant I, Aviram R, Bernardo A., Chervova A., Wankanit S, Frachon E., Commère PE., Brailly-Tabard S, Valon L, Barrio Cano L, Levayer R, Mazen I, Gobaa S, Smith JC, McElreavey K., Lovell-Badge R., Bashamboo A. Science Advances 2023 Jan 4; 9(1) 

Sreenivasan R., Gonen N., Sinclair A. SOX genes and their role in Disorders of Sex Development. Sexual Development 2022 Jun 27: 1-12

Ridnik M., Schoenfelder S., Gonen N. (2021) Cis regulatory Control of Mammalian Sex Determination. Sexual Development  2021 Oct 28:1-18

Eozenou C.*, Gonen N.*, Touzon MS.*, Jorgensen A, Yatsenko SA., Fusee L., Kamel AK., Gellen B., Guercio G., Singh P., Witchel S., Berman AJ., Mainpal R., Totonchi M.,Meybodi AM., Askari M., Merel-Chali T.,Bignon-Topalovic J., Migale R., Costanzo M., Marino R., Ramirez P., Garrido NP., Berensztein E., Mekkawy MK., Schimenti JC., Bertalan R., Mazen I., McElreavey K., Belgorosky A., Lovell-Badge R., Rajkovic A., Bashamboo A. (2020) Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene. Proc Natl Acad Sci USA

* These authors have equally contributed to this paper

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Garcia-Moreno SA., Futtner CR., Salamone IM., Gonen N., Lovell-Badge R., Maatouk DM. (2019) Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination. Dev Biol, 446(2): 168-179.

Gonen N.*, Lovell-Badge R.*. (2019) The Regulation of Sox9 expression in the Gonads. Curr Tops Dev Biol. 134:223-252 Review Article

*Co-corresponding authors

Gonen N., Futtner CR., Wood S., Garcia-Moreno SA., Salamone IM., Samson SC., Sekido R., Poulat F., Maatouk DM., Lovell-Badge R. (2018) Sex Reversal Following Deletion of a Single Far Upstream Enhancer of Sox9. Science, 360 (6396):1469-1473 

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Gonen N., Quinn A., O'Neill HC., Koopman P., Lovell-Badge R. (2017) Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 13(1).

Raz S., Sheban D., Gonen N., Stark M., Berman B., Assaraf YG. (2014) Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest. Cell Death Dis. 20;5.

Zohar-Stoopel A. *, Gonen N. *, Mahroum M., Ben-Zvi DS., Toledano H., Salzberg A. (2014) Homothorax plays autonomous and non-autonomous roles in proximodistal axis formation and migration of the Drosophila renal tubules. Dev Dyn. 243(1):132-44         

*These authors have equally contributed to this paper.

Gonen N. and Assaraf YG. (2012) Antifolates in Cancer Therapy: Structure, Activity and Mechanisms of Drug Resistance. Drug Resist Updat 15(4): 183-210. Review Article

Gonen N. and Assaraf YG. (2010) The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 (NRF-1). J. Biol. Chem. 285(44): 33602-13.

Stark M.*, Gonen N.*, Assaraf YG. (2009) Functional elements in the minimal promoter of the human proton-coupled folate transporter. Biochem. Biophys. Res. Commun. 388(1): 79-85.                   

*These authors have equally contributed to this paper.

Gonen N., Bram EE., Assaraf YG. (2008) PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells. Biochem Biophys. Res. Commun. 376(4): 787-92.