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Publications

2024

Towards a "testis in a dish": generation of mouse testicular organoids that recapitulate testis structure and expression profiles.

Stopel A., Lev C., Dahari S., Adibi O., Armon L., Gonen N.  International Journal of Biological Sciences 2024 Jan 12;20(3):1024-1041

2024

Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development

Stévant I., Gonen N.*, Poulat F.* Front Cell Dev Biol 2024 Jan 12;11:1327410

2023

Epigenetic Aging of Mammalian Gametes

Klustein M.*, Gonen N.* Molecular Reproduction and Development, 2023 Dec  90 (12):785-803

2023

In vitro cellular reprogramming to model gonad development and its disorders

Gonen N.*, Eozenou C.*, Mitter R., Elzaiat M, Stévant I, Aviram R, Bernardo A., Chervova A., Wankanit S, Frachon E., Commère PE., Brailly-Tabard S, Valon L, Barrio Cano L, Levayer R, Mazen I, Gobaa S, Smith JC, McElreavey K., Lovell-Badge R., Bashamboo A. Science Advances 2023 Jan 4; 9(1) 

2022

SOX Genes and Their Role in Disorders of Sex Development

Sreenivasan R., Gonen N., Sinclair A. SOX genes and their role in Disorders of Sex Development. Sexual Development 2022 Jun 27: 1-12

2021

Cis regulatory Control of Mammalian Sex Determination

Ridnik M., Schoenfelder S., Gonen N. (2021) Cis regulatory Control of Mammalian Sex Determination. Sexual Development  2021 Oct 28:1-18

2020

Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene

Eozenou C.*, Gonen N.*, Touzon MS.*, Jorgensen A, Yatsenko SA., Fusee L., Kamel AK., Gellen B., Guercio G., Singh P., Witchel S., Berman AJ., Mainpal R., Totonchi M.,Meybodi AM., Askari M., Merel-Chali T.,Bignon-Topalovic J., Migale R., Costanzo M., Marino R., Ramirez P., Garrido NP., Berensztein E., Mekkawy MK., Schimenti JC., Bertalan R., Mazen I., McElreavey K., Belgorosky A., Lovell-Badge R., Rajkovic A., Bashamboo A. (2020) Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene. Proc Natl Acad Sci USA

* These authors have equally contributed to this paper

2019

Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination

Garcia-Moreno SA., Futtner CR., Salamone IM., Gonen N., Lovell-Badge R., Maatouk DM. (2019) Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination. Dev Biol, 446(2): 168-179.

2019

Regulation of Sox9 expression in the Gonads

Gonen N.*, Lovell-Badge R.*. (2019) The Regulation of Sox9 expression in the Gonads. Curr Tops Dev Biol. 134:223-252 Review Article

*Co-corresponding authors

2018

Sex Reversal Following Deletion of a Single Far Upstream Enhancer of Sox9

Gonen N., Futtner CR., Wood S., Garcia-Moreno SA., Salamone IM., Samson SC., Sekido R., Poulat F., Maatouk DM., Lovell-Badge R. (2018) Sex Reversal Following Deletion of a Single Far Upstream Enhancer of Sox9. Science, 360 (6396):1469-1473 

- Recommended by Faculty of 1000 as Exceptional

- Featured in Science 

2017

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone

Gonen N., Quinn A., O'Neill HC., Koopman P., Lovell-Badge R. (2017) Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 13(1).

2014

Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.

Raz S., Sheban D., Gonen N., Stark M., Berman B., Assaraf YG. (2014) Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest. Cell Death Dis. 20;5.

2014

Homothorax plays autonomous and non-autonomous roles in proximodistal axis formation and migration of the Drosophila renal tubules

Zohar-Stoopel A. *, Gonen N. *, Mahroum M., Ben-Zvi DS., Toledano H., Salzberg A. (2014) Homothorax plays autonomous and non-autonomous roles in proximodistal axis formation and migration of the Drosophila renal tubules. Dev Dyn. 243(1):132-44         

*These authors have equally contributed to this paper.

2012

Antifolates in Cancer Therapy: Structure, Activity and Mechanisms of Drug Resistance

Gonen N. and Assaraf YG. (2012) Antifolates in Cancer Therapy: Structure, Activity and Mechanisms of Drug Resistance. Drug Resist Updat 15(4): 183-210. Review Article

2010

The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 (NRF-1)

Gonen N. and Assaraf YG. (2010) The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 (NRF-1). J. Biol. Chem. 285(44): 33602-13.

2009

Functional elements in the minimal promoter of the human proton-coupled folate transporter

Stark M.*, Gonen N.*, Assaraf YG. (2009) Functional elements in the minimal promoter of the human proton-coupled folate transporter. Biochem. Biophys. Res. Commun. 388(1): 79-85.                   

*These authors have equally contributed to this paper.

2008

PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells

Gonen N., Bram EE., Assaraf YG. (2008) PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells. Biochem Biophys. Res. Commun. 376(4): 787-92. 

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